CD274 and adenocarcinoma: The median age was 58 years (range, 32–76 years), 62 (74.7%) were male, 45 (54.2%) were smokers, 66 (79.5%) had histology of adenocarcinoma, 24 (28.9%) had driver gene alterations, 21 (25.3%) had positive PD-L1 expression, 69 (83.1%) had synchronous liver metastases, 27 (32.5%) had corticosteroid usage history and 33 (39.8%) were symptomatic.