SIRT1 and endometriosis: To further verify that METTL3-mediated regulation of EMs was dependent on SIRT1, we constructed an endometriosis model of METTL3 deletion using a CKO mouse endometriosis model, and the entire workflow is shown in Fig. 3N. Donor mouse endometrium was grafted into the recipient peritoneal cavity (labelled Day 0).