CD4 and tuberculosis: While, there were more subsets (C01: CD4+ TCM cells, C07: CD8+ TCM cells, C15: PD-1+CD8+ TRM cells, and C16: PD-1+CD8+ TEM cells) significantly changed in TB tissues under different HBV status, suggesting that HBV infections have more impact on immune signatures in TB tissues (Figs. 3C and D and Figures S3B and C).