CD4 and hepatocellular carcinoma: We found that PD-1+CD27+CD8+ TEM cell (C17), CD38low NK cell (C25), and granulocytes-2 (C31) cell clusters were significantly enriched in the advanced-stage group, while PD-1lowIL-7Ra+CD4+ TEM cells (C02) and IL-7Ra+CD8+ TEM cells (C08) in INT were more enriched in the early-stage HCC patients (Figs. 2G and H).