We confirmed that PD-1+CD8+ TRM cells were not correlated with serum HBsAg level [36], but correlated with serum ALT level, suggesting tumor progression may promote PD-1+CD8+ TRM cells to damage normal tissues as non-tumoral hepatocytes can also express HBV antigens and became the targets of HBV-specific T cells. This evidence concerns the gene PDCD1 and neoplasm.