By performing Gene Ontology (GO) pathway enrichment analysis on these shared genes in both INT and TB tissues, we found in HBV+ HCC samples, the up-regulated DEGs of PD-1+CD8+ TRM cells were enriched in oxidative phosphorylation (OXPHOS) related pathways, whereas in HBV− HCC patient the up-regulated DEGs were enriched in immune activation pathways (Fig. 5D and Figure S5A). This evidence concerns the gene PDCD1 and hepatocellular carcinoma.