IGF2BP2 and neoplasm: The IGF2BP2 and FAM83A expression-positive malignant cell subpopulations identified in this study provide cytological insights into the development of LUAD, where the LUAD_IGF2BP2 subpopulation predominates in metastatic LUAD and is involved in vesicle synthesis, signaling molecule secretion, and exosome-related biological functions, from which we suggested that tumor microenvironment reprogramming during the malignant evolution of metastatic LUAD involves intercellular communication with exosomes as the main means.