Some studies have shown that autophagy plays an influential role in the apoptosis of Müller glial cells and RGCs induced by retinal ischemic disease [41, 42].Based on our previous research [43], we demonstrated that LC3 and Beclin1 were involved in the apoptosis of RGCs in a model of acute retinal ischemia-reperfusion in rats. This evidence concerns the gene BECN1 and retinal ischemia.