In the context of cancer, high levels of HSP90 in the tumor microenvironment promote matrix remodeling that stiffens stroma, alters FN proteolytic processing and drives cell invasion and metastasis (Kass et al. 2007, Armstrong et al. 2018, Li et al. 2013; Wong and Jay 2016; Baker-Williams et al. 2019). This evidence concerns the gene FN1 and cancer.