In addition, T2DM is associated with the reduced conversion of White Adipose Tissue (WAT) to brown adipose tissue, probably due to decreased expression and activation of specific browning genes such as Uncoupling Protein 1 (UCP1) and Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-Alpha (PGC-1α)7. This evidence concerns the gene PPARGC1A and type 2 diabetes mellitus.