Other identified proteins that differentiated uncomplicated from complicated babesiosis were various complement cascade components (CFI, CFP, C2, SERPING1, C8G), extracellular matrix components (TGFBI), acute phase proteins (ORM1, ITIH2, ITIH4, FGA, TF, RBP4) and lipoproteins (apoE). This evidence concerns the gene ITIH4 and babesiosis.