Relative abundance for LTF was significantly different between the control group and complicated babesiosis (P = 0.003), apoE was significantly different between control and uncomplicated babesiosis (P < 0.001), as well as between control and complicated babesiosis (P < 0.001), while beta actin showed significant difference between control and complicated babesiosis (P < 0.001) and between uncomplicated and complicated babesiosis (P = 0.004) (Fig. 7). This evidence concerns the gene APOE and babesiosis.