The model is improved to fit not only the previously used microarray data of the human CRC cell line SW480 and its metastatic counterpart, SW62012, but also for longer timeseries of RNA-seq data for the same cells (Supplementary Figs. 1 and 2), and for the human CRC cell line HCT116 and associated KO cell lines of the core-clock genes PER2, NR1D1, and ARNTL (Fig. 2). Here, PER2 is linked to colorectal carcinoma.