As the circadian phase evaluated by ARNTL expression differs between the cell lines, we adapted the phase of the circadian protein degradation of UGT, CES, ABCB and ABCC, as well as the phase of the circadian modulation in cell death rate to the phase differences observed in ARNTL. This allows us to explore how much the toxicity profile is shifted in different clock scenarios, here represented by the various CRC cell lines used. The gene discussed is CLOCK; the disease is colorectal carcinoma.