HSP70 paralogs, especially heat shock cognate 70 (HSC70), are recruited into epichaperomes in cancer, Alzheimer’s disease (AD) and Parkinson’s disease16–19 and an epiHSP70s epichaperomics probe would provide direct access to proteome connectivity perturbations in these diseases and to the functional outcome of such changes in native biological systems22,24. The gene discussed is HSPA8; the disease is cancer.