EpiHSP70s inhibition blocked cells in mitosis, with a significantly higher impact in epiHSP70s-high cancer cells when compared to epiHSP70s-low/negative but HSP70s-high cancer cells or epiHSP70s-negative non-transformed cells, as evidenced by the G2/M population (evaluated by propidium iodide staining), cyclin B1 levels (evaluated by western blot) and the number of mitotic cells (measured by phospho-MPM2 antibody staining) (Fig. 8e, f and Supplementary Figs. 23a–c, 24a, b). This evidence concerns the gene CCNB1 and cancer.