Pancreatitis sensitizes the pancreas to the oncogenic effects of mutant Kras. We first analyzed NFIC expression in murine PanINs and PDAC from Ptf1a-Cre+/KI;KrasG12V+/KI (KC) using IHC and found that it is down-regulated in both preneoplastic and tumor cells (Fig. 7A). This evidence concerns the gene CALCA and pancreatitis.