TRPV4 and neuroblastoma: Overexpression of RhoA suppresses wild type (WT) TRPV4 channel-mediated calcium influx in cultured mouse motor neuron–neuroblastoma fusion (MN-1) cells in response to hypotonicity, demonstrating its ability to modulate TRPV4 function (Fig. 1a, b), and this effect occurs independent of changes in TRPV4 expression at the plasma membrane35.