Specifically, colon cancer marker genes such as ANXA1, FABP6, ACE2, FXYD5, LY6E, SERPINE2, SCD, BMP4, CEACAM6, TESC, and TGFBI were overexpressed in CRC organoids (Supplementary Data Fig. 2a and Supplementary Data S3). Here, LY6E is linked to colorectal carcinoma.