Specifically, colon cancer marker genes such as ANXA1, FABP6, ACE2, FXYD5, LY6E, SERPINE2, SCD, BMP4, CEACAM6, TESC, and TGFBI were overexpressed in CRC organoids (Supplementary Data Fig. 2a and Supplementary Data S3). This evidence concerns the gene SERPINE2 and malignant colon neoplasm.