BRCA1 and neoplasm: Taking into consideration our findings in this and previous studies that Brca1 deficiency stimulates Fra1 expression and reconstitution of Gata3 restores suppression of Fra1 in Brca1 deficient tumor cell during inhibition of EMT and tumorigenesis [38], we propose that the BRCA1-GATA3 axis represses FOSL1 at both transcriptional and post-transcriptional levels to doubly strengthen the inhibitory effect of BRCA1 and GATA3 in the regulation of FRA1 and FRA1-mediated EMT.