GATA3 and neoplasm: These results suggest that depletion of Gata3 suppresses the expression of c-Fos, which is, at least partially responsible for the loss of luminal and/or epithelial cell features of the tumor cells, but reconstitution of c-Fos is not sufficient to restore luminal and/or epithelial traits of Gata3 deficient tumor cells that have undergone EMT.