We uncovered that BRCA1 binds to the GATA3 binding sites in the promoter of PDGFRβ to repress its transcription and that depletion of Brca1 stimulates the expression of PDGFRβ activating the PDGFRβ-PKCα-FRA1 pathway to induce EMT and drive CSC function in breast cancer [38]. The gene discussed is PRKCA; the disease is breast cancer.