Notably, the expression of Vim and E-cad displayed a drastic inter- and intra-tumor heterogeneity in c-Fos-expressing tumors (Figs. 6E, S5D), which may reflect the unique situation that the tumor cells highly, but heterogeneously expressing both c-Fos and Fra1, the former of which activated E-cad, and the latter of which enhanced Vim. The gene discussed is FOS; the disease is neoplasm.