A MACF1 missense mutation (p.T4642S) that co-segregated with duplicate variants in CNTN6 (contactin, immunoglobulin superfamily protein) and CDH13 (cadherin-13) was associated with a rare familial psychosis with the family having genetically affected members with schizophrenia and schizoaffective disorder—two psychiatric illnesses with significant genetic overlap with BPAD [63, 64]. The gene discussed is MACF1; the disease is schizophrenia.