We next infected BMDMs and PEMs from control and VANGL2-CKO mice with VSV and sought to determine the role of VANGL2 in mediating the degradation of endogenous TBK1 during viral infection and found that VANGL2 deficiency could recover the impaired stability of TBK1 and IFN-I signaling (Fig. 4C and fig. This evidence concerns the gene VANGL2 and viral infectious disease.