We next infected BMDMs and PEMs from control and VANGL2-CKO mice with VSV and sought to determine the role of VANGL2 in mediating the degradation of endogenous TBK1 during viral infection and found that VANGL2 deficiency could recover the impaired stability of TBK1 and IFN-I signaling (Fig. 4C and fig. The gene discussed is TBK1; the disease is viral infectious disease.