The results of this study showed that age, diabetes, hemoglobin, serum albumin, edema, Braden scale score, SOFA score, APACHE II score, usage time of medical devices, use of a subglottic suction catheter, vasoconstrictors, surgery, position, and prone position ventilation might be related to the occurrence of MDRPI in ICU patients. This evidence concerns the gene ALB and diabetes mellitus.