TP53 and Cushing syndrome due to macronodular adrenal hyperplasia: As is shown in KEGG analyses, the enrichment of DEGs was most prominent along these pathways, such as cellular senescence, cell cycle, the p53 signaling pathway, oocyte meiosis, bladder cancer, cushing syndrome, endocrine resistance and progesterone−mediated oocyte maturation (Fig 2C).