For example, IFNβ overproduction is responsible for the type I interferonopathy genetic disorders, Aicardi–Goutières syndrome and Singleton–Merten syndrome, which are characterised by several symptoms associated with inflammation [33, 34], and by gain-of-function mutations in the intracellular viral RNA sensors, MDA5 and RIG-I, respectively [35]. This evidence concerns the gene IFNB1 and Aicardi-Goutières syndrome.