APOB and coronary artery disorder: Previous research has demonstrated that decreased serum Klotho levels and Klotho gene expression in the coronary artery wall are linked to the severity of coronary heart disease.[27] Animal studies have also indicated that Klotho protein could potentially promote adipocyte differentiation and play an anti-atherosclerotic role, decreasing the risk of CVD.[28] Recent studies have found a significant correlation between Klotho and blood lipids such as total cholesterol and triglyceride.[29] However, to date, there has been no investigation into the relationship between apoB and Klotho.