Recent study has shown that MORC2 is a critical regulating molecule of tumor microenvironment in immunosuppressive and pro-angiogenesis.[14] MORC2 overexpression was associated with unfavorable pathological conditions, therapy resistance, and poor OS in breast cancer.[16,32] However, the role of MORC2 in predicting NAC response and the relationship between MORC2 and pathologic response of TNBC have not been studied. This evidence concerns the gene MORC2 and breast carcinoma.