MORC2 and breast cancer: Recent study has shown that MORC2 is a critical regulating molecule of tumor microenvironment in immunosuppressive and pro-angiogenesis.[14] MORC2 overexpression was associated with unfavorable pathological conditions, therapy resistance, and poor OS in breast cancer.[16,32] However, the role of MORC2 in predicting NAC response and the relationship between MORC2 and pathologic response of TNBC have not been studied.