The gene correlation analysis of OGN showed that OMD, SFRP4, TNXB, ECM2, and CCL21 ranked top in the positive correlation, while the genes with the top negative correlation were GPI, S100A1, ENO1, TNFRSF12A, and SLA16A3. The gene discussed is SFRP4; the disease is occult macular dystrophy.