MMPs are the most important proteases for extracellular matrix degradation, and there are currently 26 members, which are divided into 5 subtypes.[29] Previous studies have shown that the overexpression of MMPs is closely related to tumor invasion, metastasis and poor prognosis.[30,31] In our study, it was found that CCL2 was positively correlated with the expression of various MMPs, such as MMP1, MMP7, MMP14, and MMP19, suggesting that CCL2 may induce tumor cell proliferation and invasion by promoting the secretion of MMPs. This evidence concerns the gene MMP1 and neoplasm.