GEPIA (http://gepia.cancer-pku.cn/) database platform [19] was used to analyze the correlation between HSF1 gene expression and prognosis(overall survival and disease free survival), and the results showed no difference in overall survival but a significant difference in disease-free survival among prostate cancer patients with high HSF1 expression (Fig. 3B, C). Here, HSF1 is linked to Familial prostate cancer.