PARP1 and neoplasm: Several PARP inhibitors are in clinical use for systemic application in tumor therapy, involving FDA-approved veliparib (Abbvie), rucaparib (Pfizer/Clovis), olaparib (KuDOS/AstraZeneca), niraparib (Merck/Tesaro), talazoparib (Lead/Biomarin/Medivation/Pfizer), and fluzoparib and pamibarib approved by the Chinese NMPA.