PARP2 deletion does not seem to influence Th2-mediated inflammatory processes, whereas the deletion or inhibition of PARP1 was anti-inflammatory in mouse models of contact hypersensitivity reaction [15–17], asthma [42], acute pancreatitis [43], allergic airway inflammation [44], and experimental colitis [45]. The gene discussed is PARP2; the disease is acute pancreatitis.