The top differentially expressed genes (DEGs) in db/db mouse endothelial cells included Malat (encoding metastasis-associated lung adenocarcinoma transcript 1), which may be involved in angiogenesis [33], and Cts3, which is dysregulated in cerebral amyloid angiopathy (Fig. 6h) [34]. This evidence concerns the gene MALAT1 and cerebral amyloid angiopathy.