Combining 4 Gy radiation with PARP-1 inhibition reduced the growth of SK-N-MC xenograft tumors, demonstrating that inhibiting PARP-1 in Ewing sarcomas can synergistically prolong and exacerbate radiation-induced DNA damage-promoting apoptotic death in an EWS-FLI1-dependent manner (Lee et al., 2013). The gene discussed is EWSR1; the disease is Ewing sarcoma.