CASP3 and breast cancer: AG14361 is capable of suppressing the growth of breast cancer cells, exhibiting respective IC50 values of 17 μM and 25 μM for 92 J-wt-BRCA1 and 92 J-sh-BRCA1 cells. It can also promote abnormalities in the cell cycle while driving the activation of caspase-3/7 and suppressing NF-κB signaling[25]. AG14361 (0.4 μM) can enhance the ability of compounds that inhibit topoisomerase I to suppress cell growth and survival without adversely affecting cleavable complex formation or reversal, increasing camptothecin-induced DNA SSB persistence