The lack of FMRP contributed significantly to the disordered brain architecture and dysregulated synaptic function (Bagni and Zukin, 2019), which may be the pathological mechanisms underlying FXS and its concomitant disorders such as depression, cognitive deficits, attention disturbance, hyperactivity (Hagerman et al., 2018). This evidence concerns the gene FMR1 and fragile X syndrome.