The deposition of extracellular “plaques” containing β-amyloid (Aβ) and the aggregation of neurofibrillary tangles consisting of hyper-phosphorylated tau protein are the pathological hallmarks of AD, which are thought to provoke progressive neurodegeneration as well as behavioral and cognitive impairment in AD (Zlokovic, 2005). This evidence concerns the gene MAPT and Alzheimer disease.