In another study, polyphenolic-rich ethanolic Spatholobus suberectus stem extract protected against ROS and cellular damage via inhibition of MMPs, upregulation of TIMP1, and the blockade of MAPK phosphorylation following UVB-induced skin photoaging in human epidermal keratinocytes (HaCaT) (Kwon et al., 2019). This evidence concerns the gene TIMP1 and neoplasm.