Notably, based on the interaction of outer membrane protein A (OmpA) with gp96 (also known as GRP94) on blood-brain barrier (BBB) endothelial cells, Gram-negative Escherichia coli K1 (EC-K1) can bind to BBB endothelial cells, and subsequently invade and cross BBB, colonizing the brain and ultimately inducing bacterial meningitis inflammation. Here, HSP90B1 is linked to bacterial meningitis.