It is reported that SCM is regarded as a promising biomimetic material because of its excellent tumor targeting and homing ability, which is mainly attributed to the interaction between the highly expressed CXCR4 on SCMs surface and the chemokine matrix derived factor 1 (SDF-1/CXCL12) released by tumor cells (Khare et al., 2021). This evidence concerns the gene CXCR4 and neoplasm.