The star signaling pathways in stroke, including the PI3K/AKT, JAK/STAT, AMPK, and MAPK pathways, play a role in angiogenesis, apoptosis, inflammation, autophagy, and oxidative stress (Jiang S. et al., 2018; Shariati and Meric-Bernstam, 2019; Arnold et al., 2021; Li N. et al., 2021). This evidence concerns the gene AKT1 and Stroke.