A variety of signaling pathways are associated with stroke, including angiogenesis (such as the Rho/Rock, Wnt/β-catenin, and NO signaling pathways), oxidative stress (including the Nrf2/ARE and SHH signaling pathways), immune inflammation (such as the NF-κB and TLRs signaling pathways), autophagy (including the Bnip3 signaling pathways), apoptosis (including the Notch and Hippo signaling pathways), ferroptosis, cuproptosis, and others such as the PI3K/AKT, MAPK, AMPK, and JAK/STAT signaling pathways. This evidence concerns the gene NFE2L2 and stroke disorder.