Polymorphisms at BMP3 have been previously reported to be associated with RE and myopia (Kiefer et al., 2013; Verhoeven et al., 2013; Hysi et al., 2020), retinal detachment (Boutin et al., 2020), and ocular coloboma (Fox et al., 2022), a congenital disorder characterized by gaps in ocular tissues. This evidence concerns the gene BMP3 and coloboma.