Another meta-analysis enrolled 99 genetic association studies, including Brazilians, concluded that the MTHFR rs1801133 polymorphism might be implicated in developing deep vein thrombosis and pulmonary embolism in non-VITT patients and may serve as a potential biological marker for venous thromboembolism in Caucasians, East Asians, and West Asians (18). This evidence concerns the gene MTHFR and venous thromboembolism.