We assessed classical hereditary thrombophilia-associated mutations: Factor V Leiden G1691A (rs6025), Factor II G20210A (rs1799963), and methylenetetrahydrofolate reductase (MTHFR), C677T (rs1801133) and A1298C (rs1801131), in addition to distinct mutations on F11 and genes related to type I IFN. The gene discussed is MTHFR; the disease is Rare hereditary thrombophilia.