A recent study analyzed the histone post-translational modifications (PTMs) of genes in SN tissues from two patients with PD and suggested two important histone methylations of H3K4 me3 and H3K27 me3 are associated with the promoter region of SNCA, which is in a range of approximately 1 kb–1.5 kb downstream of the transcription start site. This evidence concerns the gene SNCA and Parkinson disease.