In C57BL/6 and ApelaKsp KO mice, treatments with an ARG2 inhibitor, nor-NOHA, and a clinically used PGE2 synthesis activator, Paricalcitol, either separately or in combination, alleviated I/R-induced AKI; while combination treatment alleviated AKI-CKD. The gene discussed is ARG2; the disease is chronic kidney disease.