CCN2 and breast cancer: Zhu et al. described a high-effective and low-toxic multi-component vector, that was capable of facilitating gene and drug co-delivery for the treatment of drug-resistant breast cancer overexpressing connective tissue growth factor (CTGF), which encapsulated both EGCG and siRNA into a biodegradable nanogel through a self-assembly process (Figure 6G-I) 86.