Moreover, the beneficial effect of Ltf on attenuating the incidence of heart failure was counteracted by cotreatment with MHY1485, which presented with higher level of NT-proBNP, Nppa, Nppb, heart weight/tibia length and lung wet/dry ratio compared with Ltf-administrated MI group (Figure 7C; Figure S15F-H). Here, NPPA is linked to heart failure.