The mammalian orthologs of these genes, especially DVL2 and KCNA1/2, are implicated in epilepsy and episodic ataxia which are associated with both glutamate excitotoxicity and hippocampal based cognitive deficits (Aloi et al., 2022; Samanta, 2022; Muller et al., 2023). This evidence concerns the gene KCNA1 and epilepsy.