SLC1A2 and Huntington disease: Previous studies have shown that the EAAT2 is downregulated in an HD transgenic mouse model and activating the expression of EAAT2 shows rescuing of neurodegenerative phenotypes in an HD mouse model (Behrens et al., 2002; Bradford et al., 2009) implicating its neuroprotective role in glutamate uptake (Pajarillo et al., 2019).