Expression of expanded human Htt polQ peptides in Drosophila has previously been shown to result in a significant decrease in mRNA and protein levels of dEAAT1, the Drosophila homolog of mammalian EAAT2, suggesting at least a partial epigenetic repression of dEAAT1 expression in the Drosophila HD model (Liévens et al., 2005). This evidence concerns the gene SLC1A2 and Huntington disease.