Dysregulation of glutamate uptake by EAAT2 in several neurodegenerative diseases including HD has been attributed to inactivity of EAAT2 which could be due to reduced transcription of EAAT2, reduced expression of EAAT2 on the membrane, or increased degradation of EAAT2 (Hirschberg et al., 2021). This evidence concerns the gene SLC1A2 and neurodegenerative disease.