CD44 and adenoviridae infectious disease: Moreover, several DEGs were found downregulated during the progression of an adenovirus infection including DEGs involved in cell cycle and proliferation (MYC, SGK), in immune and stress response (NFE2L2, MAP2K3), in cellular structure and cell communication (CD44, KIF23), but about 50% of DEGs involved in metabolism (e.g., FKBP4, HSD17B2) were upregulated (Granberg et al., 2005).