HK2 and cancer: Insightfully, HAdV could activates MYC gene of the host to upregulates the expression of host cell glucose metabolic enzymes (specifically, hexokinase 2 and phosphofructokinase 1) through a process that mimics Warburg effect in cancer, to promote biosynthesis of nucleotide from glucose intermediates and ensure sustainable environments for its replication in primary lung epithelial cells (Thai et al., 2014).