TREM1 and infection: Co-activation of TREM-1 with these stimuli results in an increased production of cytokines.22, 23, 24, 25, 26 Translational evidence implicating TREM-1 in the pathophysiology of severe disease has been shown with a number of single strand RNA viruses.27, 28, 29 An extensive preclinical data set supporting the approach in general and specifically with nangibotide has been developed in a number of models of inflammation and infection.3