T cells from patients with 4 distinct inflammatory responses in vivo including Sickle Cell Disease (SCD) (14), GVHD, Systemic Lupus Erythematosus (SLE) and critical COVID-19 were then studied to examine Foxp3 and Helios expression to resolve whether these inflammatory environments facilitate the expression of Foxp3 in Tconv cells. This evidence concerns the gene FOXP3 and sickle cell disease.