T cells from patients with 4 distinct inflammatory responses in vivo including Sickle Cell Disease (SCD) (14), GVHD, Systemic Lupus Erythematosus (SLE) and critical COVID-19 were then studied to examine Foxp3 and Helios expression to resolve whether these inflammatory environments facilitate the expression of Foxp3 in Tconv cells. Here, FOXP3 is linked to COVID-19.