IHC on human NB patient samples reveals the higher infiltration of CD20+ B cells, CD3+ T cells, CD4+ T cells, and CD8+ T cells in early-stage tumors, followed by decreased or rare infiltration of these cells in late-stage MYCN-NA tumors and MYCN-A tumors respectively (Figures 1A, B). The gene discussed is CD8A; the disease is neuroblastoma.