Leukocyte adhesion deficiency type-1 (LAD-I), caused by mutations in ITGB2 (also known as LFA-I) integrin leading to poor neutrophile chemotaxis, is apart from other symptoms and complications, frequently characterized by severe periodontitis and this is believed to be mediated by excessive activation of an inflammatory axis rather than a simple microbial complication (35). Here, ITGB2 is linked to Leukocyte adhesion deficiency type I.