Notably, pulmonary capillary EGCX was severely damaged in HS rats, and circulating syndecan-1 and HA, two markers of EGCX, correlated positively with increased serum levels of endothelial injury marker endothelin-1, coagulation markers, and proinflammatory cytokines, indicating that EGCX injury is not only responsible for causing endothelial cell damage but also predominantly involved in the development of coagulation disorders. The gene discussed is SDC1; the disease is blood coagulation disease.