EDN1 and blood coagulation disease: Notably, pulmonary capillary EGCX was severely damaged in HS rats, and circulating syndecan-1 and HA, two markers of EGCX, correlated positively with increased serum levels of endothelial injury marker endothelin-1, coagulation markers, and proinflammatory cytokines, indicating that EGCX injury is not only responsible for causing endothelial cell damage but also predominantly involved in the development of coagulation disorders.