In the present study, we also found that changes of plasma syndecan-1 and HA in HS rats were parallel to the time of coagulation and platelet activation and correlated positively with the levels of coagulation markers, suggesting that EGCX injury may be involved in HS-initiated coagulation disorders and early protection of EGCX is therefore critical for improving prognosis of HS. The gene discussed is SDC1; the disease is blood coagulation disease.