In addition, conducting univariate and multivariate cox regression, PDHB could serve as an independent predictive marker for ccRCC patients’ overall survival (Univariate: HR=0.553, 95% CI=0.407−0.751, P<0.001; Multivariate: HR=0.696, 95% CI=0.503-0.963, P=0.029), revealing that low levels of PDHB expression were correlated with shorter OS (Figure 5D). This evidence concerns the gene PDHB and nonpapillary renal cell carcinoma.