Besides, the majority of RCC, especially clear-cell RCC (ccRCC) accounting for > 70% of tumors, is regarded as immunogenic cancer, featured by infiltration of leukocytes (natural killer cells, CD8+ T cells, and CD4+ T cells) and myeloid cells (macrophages and neutrophils) as surrounding microenvironment (41, 45). This evidence concerns the gene CD8A and renal cell carcinoma.