For example, higher levels of transmembrane collagen COL23A1, a ligan of integrin α2β1 (92) [HR = 3.024, 95% CI (1.22-7.49)] and hyaluronan, a high molecular weight unbranched polysaccharide [HR = 1.4; 95% CI (1.02-2.0)] were associated with shorter survival CD248, being identified to localize to the stromal compartment in cancers, serves a key role in myofibroblast generation and accumulation (93). Here, CD248 is linked to cancer.