The current cohort demonstrated that CRC diagnosed in patients who were 80 years or older (late-onset CRC), as compared to the traditional-onset CRC diagnosed at 50-69 years, had a substantially higher rate of dMMR disease (35%) and BRAF p.V600E mutation (35%) and increased incidences of other clinicopathological features associated with MMR deficiency. This evidence concerns the gene BRAF and mismatch repair cancer syndrome 1.