APC and mismatch repair cancer syndrome 1: Molecular features between these two age cohorts were also compared, identifying a higher rate of MMR deficiency (LO: 35% vs. TO: 8.0%) and BRAF p.V600E mutation (LO: 35% vs. TO: 8.0%), and a lower rate of APC (LO: 52% vs. TO: 78%) and TP53 mutations (LO: 53% vs. TO: 68%) in late-onset CRC (Figure 1B).