In addition to the findings of MMR deficiency and BRAF p.600E mutations, multivariate analyses also demonstrated a decrease of APC and KRAS mutations with aging and a higher incidence of KRAS and PIK3CA mutations and a low incidence of TP53 mutations in the right-sided CRC, consistent with the previous reports (23–25). This evidence concerns the gene KRAS and mismatch repair cancer syndrome 1.