However, the incidences of dMMR/BRAF-APC- (8.3% vs. 1.2%) and pMMR/BRAF+APC- (12% vs. 4.0%) were also significantly higher in the late-onset CRC as compared to traditional-onset CRC, suggesting additional mechanisms independently contribute to a higher rate of MMR deficiency and BRAF p.V600E mutation in late-onset CRC. Here, BRAF is linked to mismatch repair cancer syndrome 1.