When the late-onset CRC (≥ 80y) was compared to the traditional-onset CRC (50-69y), there was also a significantly higher rate of dMMR/BRAF+APC- CRC (18% vs. 2.0%), dMMR/BRAF-APC- CRC (8.3% vs. 1.2%) and pMMR/BRAF+APC- CRC (12% vs. 4.0%) and a significantly lower incidence of pMMR/BRAF-APC+ CRC (43% vs. 72%) (Figure 5). Here, BRAF is linked to colorectal carcinoma.