Our results showed that CXCR3 was upregulated in the tumor tissues after PKU12 + siRNA treatment, and high expression of CXCR3 may predict better a prognosis in patients with cervical cancer, suggesting that the anti-tumor effects of knockdown for HPV16 oncoproteins may be mediated via upregulating CXCR3 in cervical cancer. The gene discussed is CXCR3; the disease is neoplasm.