Among the 27 study samples, there were only 4 cases of disagreement between HER2-SRM and pathological diagnosis, and the remaining 23 cases were accurately predicted, showing the good accuracy of HER2-SRM method in determining the pathological diagnosis of whether mixed-type gastric adenocarcinoma (Lauren classification) has intestinal phenotype features. This evidence concerns the gene ERBB2 and gastric adenocarcinoma.