Moreover, the SWI/SNF complex and the PRC2 complex containing EZH2 methyltransferase have been shown antagonistic activity in gene transcription (104, 105), of which EZH2 has an obvious anti-tumor effect on cell lines and xenografts with concurrent loss of SMARCA2 and SMARCA4 (106, 107). The gene discussed is EZH2; the disease is neoplasm.